Localized proton MRS of animal brain in vivo: Models of human disorders
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چکیده
2008 Elsevier B.V. All rights reserved.
منابع مشابه
Measurement of T1 relaxation times of major metabolites in the mouse brain at 11.7 and 17.6 Tesla using voxel-localized proton magnetic resonance spectroscopy
T. Neuberger, A. Webb, C. Faber, V. C. Behr, S. Neubauer, J. E. Schneider Department of Bioengineering, Huck Institute Magnetic Resonance Centre, University Park, PA, United States, Experimental Physics V, UNIVERSITY OF WUERZBURG, Wuerzburg, Germany, Department of Cardiovascular Medicine, UNIVERSITY OF OXFORD, Oxford, United Kingdom Introduction: Localized proton MR spectroscopy can be used to ...
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Introduction Currently a definitive diagnosis of Alzheimer’s disease (AD) is only possible postmortem, by detecting the two hallmarks of the disease: amyloid plaques and neurofibrillary tangles in the brain tissue. There is thus a great need for in vivo biomarkers to diagnose AD with high specificity and sensitivity. Proton magnetic resonance spectroscopy (H MRS) provides a non-invasive way to ...
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We describe a localized proton magnetic resonance spectroscopy ((1)H-MRS) method for in vivo measurement of lipid composition in very small voxels (1.5 mm x 1.5 mm x 1.5 mm) in adipose tissue in mice. The method uses localized point-resolved spectroscopy to collect (1)H spectra from voxels in intra-abdominal white adipose tissue (WAT) and brown adipose tissue (BAT) deposits. Nonlinear least-squ...
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Localized in vivo proton magnetic resonance spectroscopy ((1)H-MRS) has been used to measure the metabolic status of the human brain in a non-invasive manner; thus, it is often called "a non-invasive biochemical assay". MRS is more sensitive than magnetic resonance imaging (MRI) in detecting ischemic damage by measuring the metabolic changes that occur prior to the anatomic changes. We report a...
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Localized proton magnetic resonance spectroscopy (H MRS) became an important tool for investigating brain metabolism non-invasively. In animal models, high field H MRS allows detection of almost 20 metabolites [1-4], also called the neurochemical profile (taurine (Tau), creatine (Cr), phosphocreatine (PCr), phosphocholine (PCho), glycerophosphocholine (GPC), glutamate (Glu), glutamine (Gln), my...
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